Destruction may refer to:

• The act of destroying something.
• Slighting, the act of damaging an important building
• Destruction (band), a German thrash metal band
• Destruction (DC Comics), one of the Endless in Neil Gaiman's comic book series The Sandman
• Destruction Bay, Yukon, Canada
• a magic art in the computer role-playing game series The Elder Scrolls
• Appetite for Destruction, the breakthrough debut album of rock n' roll band Guns N' Roses