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(R)-ibuprofen
Ibuprofen
Systematic (IUPAC) name
(RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid
Identifiers
CAS number15687-27-1
ATC codeC01EB16 G02CC01 M01AE01 M02AA13 R02AX02
PubChem3672
DrugBankDB01050
ChemSpider3544
Chemical data
FormulaC13H18Template:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxO2Template:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox 
Mol. mass206.29 g/mol
SMILESeMolecules & PubChem
Synonymsisobutylphenylpropionic acid
Physical data
Density1.03 g/ml g/cm³
Melt. point75–78 °C (167–172 °F)
Boiling point157 °C (315 °F) at 4 mmHg
Solubility in water0.021 mg/mL (20 °C)
Pharmacokinetic data
Bioavailability80–100% (by mouth), 87% (rectal)
Protein binding98%
MetabolismLiver (CYP2C9)
Half life2–4 h
ExcretionUrine (95%)
Therapeutic considerations
Licence data

EU EMEA:linkUS FDA:link

Pregnancy cat.

C(AU) C(US) D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus

Legal status

?(AU) ?(CA) GSL(UK) OTC(US)

Routesby mouth, rectal, topical, and intravenous

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) created by British chemist Stewart Adams. It is used to stop pain, help reduce fevers, relieve arthritis pain, and acts as an inflammatory part. Ibuprofen is used to relieve pain from various conditions such as headache, dental pain, menstrual cramps, muscle aches, or arthritis. It is also used to reduce fever and to relieve minor aches and pain due to the common cold. If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

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