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Oxycodone
Systematic (IUPAC) name
(5R,9R,13S,14S)-4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
Identifiers
CAS number76-42-6
ATC codeN02AA05
N02AA55 (in combinations)
PubChem5284603
DrugBankDB00497
ChemSpider4447649
Chemical data
FormulaC18H21Template:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxNTemplate:OrganicBoxO4Template:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox 
Mol. mass315.364 g/mol
SynonymsEukodal, eucodal; dihydrohydroxycodeinone, 7,8-dihydro-14-hydroxycodeinone, 6-deoxy-7,8-dihydro-14-hydroxy-3-O-methyl-6-oxomorphine
Physical data
Melt. point219 °C (426 °F)
Solubility in waterHCl: 166 mg/mL (20 °C)
Pharmacokinetic data
BioavailabilityBy mouth: 60–87%
Protein binding45%
MetabolismLiver: mainly CYP3A, and, to a much lesser extent, CYP2D6 (~5%); 95% metabolized (i.e., 5% excreted unchanged)
Half lifeBy mouth (IR): 2–3 hrs (same 1/2 for all ROAs)
By mouth (CR): 4.5 hrs
ExcretionUrine (83%)
Therapeutic considerations
Pregnancy cat.

C(AU) B(US)

Legal status

Controlled (S8)(AU) Schedule I(CA) Class A(UK) Schedule II(US)

Dependence LiabilityHigh
RoutesBy mouth, sublingual, intramuscular, intravenous, intranasal, subcutaneous, transdermal, rectal, epidural

Oxycodone is a medicine that is used to treat pain. This kind of pain medicine is called an analgesic.

Oxycodone is a man-made opioid. This means that in the body, it acts like morphine, a powerful, natural painkiller. The chemical elements in oxycodone are very similar to codeine, another natural painkiller.

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