The Vaucluse (Occitan: Vauclusa) is a department in the southeast of France in the Provence-Alpes-Côte d'Azur region. Its prefecture is Avignon.
It is named after a famous spring, in the commune Fontaine-de-Vaucluse. The name Vaucluse comes from the Latin Vallis Clausa ("closed valley") as the valley here ends in a cliff from which rises a spring.