To be sick can mean:

• Having a disease, illness, or disorder

Sick may also refer to:

• Sick comedy, an expression used to attack the social criticism of the new late 1950s comedians
• Sick (magazine), a humour magazine
• Sick (Sow album), an album by Sow
• Sick (Massacra album), an album by Massacra
• "Sick" (Young Ones episode), the 11th episode of the British comedy The Young Ones
• "Sick, Sick, Sick", a song by Queens of the Stone Age
• SICK: The Life & Death of Bob Flanagan, Supermasochist, a 1997 documentary about Bob Flanagan
• Sick AG, a German sensor technology corporation which built the laser range-finders used on the robot Stanley
• Gary Sick, a writer