Loco could mean:

• Loco (loa), a Rada nation patron of healers and plants
• Loco (song), the first single by the band Coal Chamber
• An abbreviation for locomotive
• The Chilean and Peruvian name for the local Abalone
• Loco (Audio Programming Language), is an audio programming language designed to be for sound what Logo is for graphics
• Loco (album), a 2001 song and album by the Fun Lovin' Criminals
• Loco Linux, a Linux distribution
• Loco, Oklahoma is a place in Stephens County
• Loco, Switzerland
• The nickname of Manuel Antonio Cange, a footballer
• Loco team, a group of Linux and open source advocates
• Loco (Gobots), a character from the Gobots toyline
• Loco (MÄR) - A fictional character in the manga and anime series MÄR
• LocoRoco - Game for PlayStation