Handle could mean:

• Handle (grip), a device, attached to an object, that is held to move or use the object
• Handle (mathematics), a term used in topology
• Handle, the friction and flexibility of sheets of material as measured by Handle-o-Meter
• Handle, a pseudonym used in Citizens band radio
• Handle or username, a pseudonym used within an online system
• Adjustment handles let a user interface designer resize a control.
• A handle is a 1.760001 liter (approx. half gallon) bottle of a distilled beverage because bottles of that size often have a handle
• Handle, the total amount bet at a place such as a horse racing track, dog racing track, or jai alai fronton
• A doorhandle.