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Aspirin
INN: acetylsalicylic acid
Aspirin-skeletal.svg
Aspirin-B-3D-balls.png
Clinical data
Pronunciationacetylsalicylic acid /əˌsəlˌsælɪˈsɪlɪk/
Trade namesBayer Aspirin, many others
Synonyms2-acetoxybenzoic acid
acetylsalicylate
acetylsalicylic acid
O-acetylsalicylic acid, Aspirin (BAN UK), Aspirin (USAN US)
AHFS/Drugs.comMonograph
MedlinePlusa682878
License data
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out) D in the 3rd trimester
Routes of
administration
by mouth, rectal, lysine acetylsalicylate may be given intravenously or intramuscularly
ATC code
Legal status
Legal status
  • AU: S2 (Pharmacy only) except when given intravenously (in which case it is schedule 4), used in animal medicine (schedule 5/6) or when the dose is higher than usual.
  • UK: General sales list (GSL, OTC)
  • US: OTC
Pharmacokinetic data
Bioavailability80–100%
Protein binding80–90%
MetabolismLiver, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall.
Elimination half-lifeDose-dependent; 2 h to 3 h for low doses (100 mg or less), 15 h to 30 h for large doses.
ExcretionUrine (80–100%), sweat, saliva, feces
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}
Chemical and physical data
FormulaC9H8O4
Molar mass180.158 g/mol
3D model (JSmol)
Density1.40 g/cm3
Melting point136 °C (277 °F)
Boiling point140 °C (284 °F) (decomposes)
Solubility in water3 mg/mL (20 °C)
  (verify)

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Aspirin (acetylsalicylic acid) is a drug. It is most commonly used as a pain killer, or to reduce fever or inflammation. It also has an anti-platelet effect - it reduces the number of platelets in the blood which reduces blood clotting- in that function it is used to prevent heart attacks. Aspirin is one of the most-used medical drugs in the world.

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