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Pronunciation | acetylsalicylic acid /əˌsiːəlˌsælɪˈsɪlɪk/ |
Trade names | Bayer Aspirin, many others |
Synonyms | 2-acetoxybenzoic acid acetylsalicylate acetylsalicylic acid O-acetylsalicylic acid, Aspirin (BAN UK), Aspirin (USAN US) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682878 |
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Routes of administration | by mouth, rectal, lysine acetylsalicylate may be given intravenously or intramuscularly |
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Pharmacokinetic data | |
Bioavailability | 80–100% |
Protein binding | 80–90% |
Metabolism | Liver, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall. |
Elimination half-life | Dose-dependent; 2 h to 3 h for low doses (100 mg or less), 15 h to 30 h for large doses. |
Excretion | Urine (80–100%), sweat, saliva, feces |
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PDB ligand | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}} |
Chemical and physical data | |
Formula | C9H8O4 |
Molar mass | 180.158 g/mol |
3D model (JSmol) | |
Density | 1.40 g/cm3 |
Melting point | 136 °C (277 °F) |
Boiling point | 140 °C (284 °F) (decomposes) |
Solubility in water | 3 mg/mL (20 °C) |
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Aspirin (acetylsalicylic acid) is a drug. It is most commonly used as a pain killer, or to reduce fever or inflammation. It also has an anti-platelet effect - it reduces the number of platelets in the blood which reduces blood clotting- in that function it is used to prevent heart attacks. Aspirin is one of the most-used medical drugs in the world.