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Secretary of State is a title for a government official. The title has different meanings in different countries, and in some cases there are several Secretaries of State in the government.

In many countries, a secretary of state is a mid-level official.

• In the United Kingdom a secretary of state is a senior minister in the Cabinet.

• In the Vatican City the Cardinal Secretary of State is the head of the Roman Curia which is the cabinet of the Vatican and the Roman Catholic Church.